On behalf of the IAOP and AAOMP, it is with enthusiasm that we invite you to Vancouver, Canada for this joint meeting.  The scientific component of the meeting will highlight various symposia, lectures, and slide seminars, which will meet our highest expectations of research and scholarship.  It is the mission of both the IAOP and AAOMP to advance the science and practice of Oral and Maxillofacial Pathology and this meeting will undoubtedly achieve this aim.  We encourage as many of the attendees as possible, to present their research in either a poster or platform presentation format to further achieve the goals of this congress.

The meeting will be held at the Westin Bayshore Hotel.  Experience the unbridled energy of downtown Vancouver, BC with a visit to this hotel. Boasting unparalleled views of the mountains, the coastline, and scenic Stanley Park, The Westin Bayshore, Vancouver provides an elegant, restful base from which to explore.  The meeting will also provide a number of social events to help foster friendships and potential scientific collaborations.

The last joint meeting was in San Francisco in 2008 and the bonds of fellowship formed at that time still exist today, with new bonds surely to be developed with our veteran and younger members.   It is therefore a privilege for the IAOP to work with the AAOMP ten years later; and the AAOMP is most appreciative of the opportunity to host our international colleagues.

We look forward to welcoming you to Vancouver.

 

Dr. Steven Vincent, AAOMP President

 

                                                                                  

Dr. WM Tilakaratne, IAOP President 

 

                                                       

2018 AAOMP & IAOP Joint Meeting

Register Now

  • June 23 - 28, 2018
  • 1601 Bayshore Dr,
    Vancouver, British Columbia
    Canada
    V6G 2V4

Event Workshops

AAOMP Seminar - Drs. Martin Hyrcza, Iona Leong, Christina McCord, Catherine Poh, Firoozeh Samim, Marco Magalhaes

June 24, 2018  08:00 - 11:30
Fee: $0.00
Seats Remaining:340

AAOMP Seminar

Moderator: Grace Bradley, DDS, MSc, FRCD(c)

Speakers: Drs. Martin Hyrcza, Iona Leong, Christina McCord, Cathering Poh, Firoozeh Samim, Grace Bradley, Marco Magalhaes

* All of the speakers involved in this seminar have been verified as having no relevant financial relationships to disclose.

Course Description (3.5 credit hours):

Ten cases of Head and Neck Pathology will be presented as unknown cases. Virtual slide scans and short case histories will be made available to course participants ahead of time so that participants can submit their diagnoses for discussion at the seminar. The cases will be selected to cover a range of histopathologic diagnoses and each poses a diagnostic challenge that will stimulate discussion and review of the pertinent literature.

Objectives of course:

  1. Examine pathology cases that represent recently described entities and discuss them in the context of related pathologic conditions.
  2. Analyze cases that present a diagnostic challenge and require correlation of histomorphology, immunohistochemical staining and molecular genetics to arrive at a diagnosis.

At the end of this course the participants will have:

  • increased their insight into the 10 lesions that were presented, including the diagnostic criteria, differential diagnoses and disease classification
  • reviewed the recent literature pertaining to the 10 lesions
  • refined their approach to diagnosis of this group of lesions

 

 

Translational Aspect Of Tumor Microenvironment In The Head And Neck Cancer - Drs. Tuula Salo, Dan Lambert, Toshinari Mikami, Gareth Thomas

June 25, 2018  08:00 - 11:00
Fee: $0.00
Seats Remaining:339

Symposium #1

Translational Aspect of Tumor Microenvironment in the Head and Neck Cancer

Speakers: * All of the speakers involved in this seminar have been verified as having no relevant financial relationships to disclose.

Tuula Salo, DDS, PhD - “The role of extracellular matrix in analysing oral cancer cells behaviour

Course Description (3 credit hours):

This lecture, “The role of extracellular matrix in analysing oral cancer cells behaviour” will describe the current knowledge related to the role of extracellular matrix (ECM) molecules and cells in oral cancer invasion. During last decades, it has become more and more clear that ECM essentially contribute in oral cancer progression.  In vitro cancer research has lacked human tissue models that mimic the natural tumor microenvironment (TME) matrix. 3D invasion and growth of carcinoma cells has been investigated using organotypic models composed of rat tail type I collagen combined with tumor derivatives, such as basement membrane molecules containing matrix, Matrigel®. These classical methods mix matrices from different species and do not accurately mimic the composition of human tumor ECM.

Objectives of course:

  • The aim of this lecture is to describe the benefits of using human benign uterine leiomyoma tissue derived 3D invasion assays for oral cancer in vitro research. These myoma disc and myogel models contain all the essential TME components for in vitro experiments. Myoma assay fit also for co-culture experiments of various TME cells, such as carcinoma associated fibroblasts, macrophages and inflammatory cells. Myogel provides an excellent matrix for monitoring cancer cell migration, invasion and adhesion properties. Additionally, we found myogel superior to 2D plastic and Matrigel in analysing the effects of anticancer drugs. Thus, myoma discs together with myogel offer practical human matrices for translational cancer research purposes.

At the end of this part of the course the participant should:

  • Be aware of the importance of using human tumor derived extracellular matrices to investigate the interaction between human cancer and ECM cells and molecules.
  • Additionally, the participant should recognize the value of applying 3D human tumor derived matrix to measure the preclinical effects of oral cancer drugs.

Dan Lambert, BSc, PhD - Extracellular vesicles in the tumour microenvironment

Course Description:

In recent years, interest in the biology and clinical utility of small membrane-bound vesicles released by cells, collectively termed extracellular vesicles (EVs) has exploded. EVs, encompassing a range of vesicles such as exosomes and microvesicles, carry cargo including RNA, DNA and protein (as well as lipid components) that are able to influence the behavior of surrounding and distant cells. In cancer, EV-mediated interactions have been shown to influence every stage of the development and spread of disease. In this course, I will discuss the current understanding of the influence of EVs on the interactions and phenotype of cells of the tumor microenvironment, with particular emphasis on head and neck cancer, and will highlight controversies in the field. In addition I will highlight the potential of EVs in the clinic in relation to oral and other cancers.

Objectives of course:

  • Gain an understanding of the basic biology of EVs
  • Be aware of controversies in the field, and technical challenges
  • Appreciate the translational potential of this course

At the end of this course the participant:

  • Will have a good understanding of the nature and function of extracellular vesicles, what is known about their roles in the tumor microenvironment, and their potential for translation to the clinic. 

Toshinari Mikami, DDS, PhD - "Microenvironment of odontogenic tumor, development and epithelial to mesenchymal transition"

Course Description:

Odontogenic tumors are heterogeneous lesions derived from the epithelial and/or mesenchymal elements of tooth forming apparatus and their remnants. These tumors exhibit various biological behaviors ranging from hamartoma-like lesion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. Most odontogenic tumors occur in the jaw bone and rarely occur on the periphery. In addition, since the tumor cells migrate out of the bone after marsupialization; the tumor microenvironment differs from case to case. It is known that epithelial to mesenchymal transition (EMT) is involved in tumor invasion and metastasis; however, the association between EMT and development of odontogenic tumors remains unclear. As the tooth germ differentiates through the interaction of epithelium and mesenchyme in the early stage, expression profiles of epithelial and mesenchymal markers vary in tumors and the degree of differentiation. In this context, understanding the microenvironment of odontogenic tumor is complicated. The present lecture focuses on how odontogenic tumor cells change their characters in the tumor microenvironment from the EMT perspective.

Objectives of course:

  • To introduce and discuss the microenvironment of the tumor from the EMT perspective.

At the end of this course the participant:

  • It is anticipated that the participants will understand how EMT is associated with tumor growth in the tumor microenvironment of odontogenic tumor.

Gareth Thomas, BDS, MScD, PhD, FDSRCS. FRCPath – “Tumor Microenvironment: Impacts on Molecular Classification, Prognosis and Response to Immunotherapy”

Course Description:

The lecture will discuss the role of the tumour microenvironment in head and neck cancer; how this impacts on molecular classification, prognosis and response to immunotherapy.  The role of various cell types in regulating the anti-tumour immune response will be discussed, as will recent advances in ‘omic’ technologies which have informed our understanding of molecular phenotypes and cell heterogeneity.  The translational potential of these technologies in identifying predictive biomarkers and developing strategies for drug combinations will be explored. 

Objectives of Course

  • Describe the importance of the tumour microenvironment in head and neck cancer progression, particularly the prognostic and predictive significance of various cell types.
  • Discuss how advances in sequencing technologies are informing our understanding of the molecular phenotypes of head and neck cancers, and describe advances in this field.

 

At the end of this course the participant:

  • Will have an understanding of how the tumour microenvironment influences disease progression and response to therapy, and how treatment strategies are being developed based on a deeper understanding of the molecular mechanisms that regulate the anti-tumour immune response.

 

Challenging Dermatopathology Of The Head And Neck - Dr. Rossitza Lazova

June 26, 2018  09:00 - 12:00
Fee: $0.00
Seats Remaining:355

Symposium #2

Speaker: Rossitza Lazova, MD

"Challenging Dermatopathology of the Head and Neck"

* This speaker has been verified as having no relevant financial relationships to disclose.

Course Description (3 credit hours):

This session will explore a range of inflammatory skin conditions and neoplastic processes of the head and neck area, which can cause diagnostic dilemmas and create pitfalls. An in-depth discussion will focus on the histological and clinicopathological aspects of each case. A diagnostic approach to these challenging cases and how to avoid diagnostic pitfalls will be presented. Appropriate laboratory evaluation and new molecular diagnostic tools will be discussed. 

Objectives of course:

  • To provide participants with knowledge and tools to be able to arrive at the correct diagnosis or generate an appropriate differential diagnosis of challenging cases.
  • The knowledge gained from this course can be applied to deliver optimum care and improve patient outcomes.

At the end of this course the participant:

  • Be able to apply morphological criteria to differential diagnoses of cutaneous lesions
  • Generate clinically relevant differential diagnosis for neoplastic and inflammatory skin conditions
  • Demonstrate an approach toward diagnosis of complex, challenging skin biopsies
  • Utilize appropriate ancillary studies

 

Case Studies Involving Head And Neck Radiology - Dr. Thomas Underhill

June 27, 2018  08:00 - 11:00
Fee: $0.00
Seats Remaining:378

Symposium #3

Speaker: Thomas Underhill, MD

"Case Studies Involving Head and Neck Radiology"

* This speaker has been verified as having no relevant financial relationships to disclose.

Course Description (3 credit hours):

Cone beam CT (CBCT) has become universally accepted in maxillofacial imaging. Multiplanar imaging in dentistry is now commonplace. Ideally, the pathologist should be presented with both radiographic images and radiographic report along with the pathology specimen.   A formal radiographic interpretation may or may not be available.  When performing a clinical consultation, the pathologist may need to suggest appropriate imaging.

Objectives:

  • This course will present the radiographic appearance of various head and neck lesions. 
  • Basic radiographic interpretation of principles of CBCT and other imaging modalities will be discussed.  With the use of CBCT, more incidental findings are observed. 
  • Common incidental findings, such as vascular calcifications, will be discussed.  Emphasis will be placed on both CBCT and multidetector CT.  
  • Appropriateness of CBCT versus multidetector CT (MDCT)  will be discussed. 
  • Other imaging modalities will also be shown when appropriate, including PET scan, CT, MRI and ultrasound.

At the end of this course the participants will:

  •  Have knowledge of common incidental findings that appear on CBCT imaging.
  •  Know which incidental findings need a referral or follow up.
  • Understand the principle differences between CBCT and MDCT.
  • Know when CBCT is the appropriate imaging technique.
  • Recognize salient features of benign vs. aggressive vs. malignant lesions.
  • Understand when other imaging techniques such as MRI or ultrasound may be beneficial.

 

Clinical Pathology Course (CPC)

June 28, 2018  08:00 - 12:00
Fee: $0.00
Seats Remaining:401

Clinical Pathology Conference

Speakers:  TBA

* All of the speakers involved in this seminar have been verified as having no relevant financial relationships to disclose.

Course Description: (4 credit hours)

Contributors and Discussants from both organizations will be presenting.